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Over-the-counter vs Prescription Xyzal (Levocetirizine) Until 2017, levocetirizine tablets were available in the US only by prescription from a doctor. Prescription medication is not always the best. Xyzal contains levocetirizine, an antihistamine previously only available with a prescription Overview Xyzal (Levocetirizine) is an allergy medication that is available over the counter beginning Spring 2017. In January 2017, the FDA deregulated levocetirizine and allowed it for sale without a prescription (over-the-counter) OTC Xyzal Allergy 24HR is the same strength as the prescription product. Xyzal contains levocetirizine, an antihistamine previously only available with a prescription Xyzal OTC is dosed once daily and lasts 24 hours per dose. (desloratadine), or Xyzal (levocetirizine) Go OTC Alavert, Claritin (or generic loratadine), or Zyrtec (cetirizine) Save as much as 8 a month*. Correction: Proteome-wide analysis of chaperone-mediated autophagy targeting motifs. 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